Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses LONG CHI NGUYEN, DONGBO YANG, VLAD NICOLAESCU, THOMAS J. BEST, HALEY GULA, DIVYASHA SAXENA, JON D. GABBARD, SHAO-NONG CHEN, TAKASHI OHTSUKI, JOHN BRENT FRIESEN, NIR DRAYMAN,…
Richard B. van Breemen*Ruth N. MuchiriTimothy A. BatesJules B. WeinsteinHans C. LeierScotland FarleyFikadu G. Tafesse Publication Date:January 10, 2022 https://doi.org/10.1021/acs.jnatprod.1c00946 Abstract As a complement to vaccines, small-molecule therapeutic agents are…
an article by Emily Earlenbaugh In the fight against Covid-19, cytokine storms are one of the most deadly factors that doctors are battling. This symptom in severe cases of the novel coronavirus…
El Biali M.· Broers B. · Besson M. · Demeules J. https://doi.org/10.1159/000510799 Abstract Since the endocannabinoid system is involved in immune function, the effect of cannabinoid intake on infectious conditions is questioned for several years and…
Long Chi Nguyen, Dongbo Yang, Vlad Nicolaescu, Thomas J. Best, Takashi Ohtsuki, Shao-Nong Chen, J. Brent Friesen, Nir Drayman, Adil Mohamed, Christopher Dann, Diane Silva, Haley Gula, Krysten A. Jones, J. Michael Millis, Bryan C. Dickinson, Savaş Tay, Scott A. Oakes, Guido F. Pauli, David O. Meltzer, Glenn Randall, Marsha Rich Rosner doi: https://doi.org/10.1101/2021.03.10.432967 ABSTRACT The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD),…
by Barbara Malinowska, Marta Baranowska-Kuczko , Aleksandra Kicman and Eberhard Schlicker Int. J. Mol. Sci.2021, 22(4),1986; https://doi.org/10.3390/ijms22041986 Received: 11 January 2021 / Revised: 11 February 2021 / Accepted: 12 February 2021 / Published: 17…
Figure: Potential mechanisms associated with cannabinoid mediated suppression of SARS-CoV-2 induced lung inflammation and fibrosis. ROS- Reactive oxygen species, IL- Interleukin; IFN- Interferon; MIP- Macrophage inhibitory protein; MCP- Monocyte chemotactic…
Figure: Inflammatory response in lung after coronavirus (SARS-CoV-2) infection. Lung susceptibility to SARS-CoV-2 infection depends on viral spike proteins specificity for angiotensin-converting enzyme 2 (ACE2) receptors on alveolar epithelial cells.…
Figure : Effects of novel C. sativa extracts on the levels of pro-inflammatory cytokines. To induce inflammation, human 3D EpiDermFT tissues were exposed to UV. Upon exposure, tissues were incubated with extracts or vehicle…
Figure: Summary of CBD’s mechanisms of immune suppression. Overall, CBD’s immune system suppression is mediated by direct inhibition of various cell types (microglial, innate, and T cells) and induction of…