El Biali M.· Broers B. · Besson M. · Demeules J.

https://doi.org/10.1159/000510799

Abstract

Since the endocannabinoid system is involved in immune function, the effect of cannabinoid intake on infectious conditions is questioned for several years and is of particular interest in the COVID 19 pandemia. Some data suggest that the immunomodulatory effect of cannabinoids may affect the course and severity of SARS-CoV-2 infection. Given the large number of cannabinoids consumers in the community, this commentary presents the current knowledge on the potential impact of cannabinoids and endocannabinoids on bacterial and viral infection courses namely SARS-CoV-2 disease. Practical recommendations, which can be drawn from the literature, are given.

Link between ECs and the Immune System

The wide expression of CB2 in the immune system and to a lesser extent CB1 suggests that cannabinoid receptors, once activated, may be involved in immune system functions. In addition, AEA and 2-AG can modulate inflammation without necessarily binding to their receptors owing to their arachidonic acid-containing structure, which make them precursors of anti-inflammatory lipids.

Conclusion

ECS has a modulating effect on the immune system, but people taking cannabinoids or cannabis are not considered immunosuppressed. No studies are currently available on the incidence and course of SARS-CoV-2 infection (COVID-19) in persons taking cannabinoids.

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